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Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans

机译:秀丽隐杆线虫生物膜介导的抗逆性和寿命延长的机制

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摘要

Bacteria naturally form communities of cells known as biofilms. However the physiological roles of biofilms produced by non-pathogenic microbiota remain largely unknown. To assess the impact of a biofilm on host physiology we explored the effect of several non-pathogenic biofilm-forming bacteria on Caenorhabditis elegans. We show that biofilm formation by Bacillus subtilis, Lactobacillus rhamnosus and Pseudomonas fluorescens induces C. elegans stress resistance. Biofilm also protects against pathogenic infection and prolongs lifespan. Total mRNA analysis identified a set of host genes that are upregulated in response to biofilm formation by B. subtilis. We further demonstrate that mtl-1 is responsible for the biofilm-mediated increase in oxidative stress resistance and lifespan extension. Induction of mtl-1 and hsp-70 promotes biofilm-mediated thermotolerance. ilys-2 activity accounts for biofilm-mediated resistance to Pseudomonas aeruginosa killing. These results reveal the importance of non-pathogenic biofilms for host physiology and provide a framework to study commensal biofilms in higher organisms.
机译:细菌自然形成称为生物膜的细胞群落。然而,由非致病性微生物群产生的生物膜的生理作用仍然是未知的。为了评估生物膜对宿主生理的影响,我们探索了几种非致病性生物膜形成细菌对秀丽隐杆线虫的影响。我们表明由枯草芽孢杆菌,鼠李糖乳杆菌和荧光假单胞菌的生物膜形成诱导线虫线虫的抗逆性。生物膜还可以防止病原体感染并延长使用寿命。总mRNA分析确定了一组宿主基因,这些基因在枯草芽孢杆菌对生物膜形成的响应中被上调。我们进一步证明了mtl-1负责生物膜介导的抗氧化应激性和寿命延长。诱导mtl-1和hsp-70促进生物膜介导的耐热性。 ilys-2活性解释了生物膜介导的对铜绿假单胞菌杀伤的抗性。这些结果揭示了非致病性生物膜对于宿主生理学的重要性,并提供了研究高等生物中共生生物膜的框架。

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