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Digital Biosensing by Foundry-Fabricated Graphene Sensors

机译:铸造石墨烯传感器的数字生物传感

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摘要

The prevailing philosophy in biological testing has been to focus on simple tests with easy to interpret information such as ELISA or lateral flow assays. At the same time, there has been a decades long understanding in device physics and nanotechnology that electrical approaches have the potential to drastically improve the quality, speed, and cost of biological testing provided that computational resources are available to analyze the resulting complex data. This concept can be conceived of as “the internet of biology” in the same way miniaturized electronic sensors have enabled “the internet of things.” It is well established in the nanotechnology literature that techniques such as field effect biosensing are capable of rapid and flexible biological testing. Until now, access to this new technology has been limited to academic researchers focused on bioelectronic devices and their collaborators. Here we show that this capability is retained in an industrially manufactured device, opening access to this technology generally. Access to this type of production opens the door for rapid deployment of nanoelectronic sensors outside the research space. The low power and resource usage of these biosensors enables biotech engineers to gain immediate control over precise biological and environmental data.
机译:生物测试中流行的哲学是将重点放在具有易于解释的信息的简单测试上,例如ELISA或侧流分析。同时,在设备物理学和纳米技术领域已有数十年的长期了解,只要计算资源可用于分析所产生的复杂数据,电学方法就有可能极大地提高生物测试的质量,速度和成本。可以将这个概念视为“生物的互联网”,就像微型电子传感器支持“物联网”一样。在纳米技术文献中已经很好地证明,诸如场效应生物传感的技术能够进行快速而灵活的生物测试。到目前为止,仅限于专注于生物电子设备及其合作者的学术研究人员才能使用这项新技术。在这里,我们证明了这种能力保留在工业制造的设备中,从而为该技术打开了通行渠道。获得此类产品的途径为在研究空间外快速部署纳米电子传感器打开了大门。这些生物传感器的低功耗和资源消耗使生物技术工程师能够立即控制精确的生物和环境数据。

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