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Neuroanatomical Framework of the Metabolic Control of Reproduction

机译:生殖代谢控制的神经解剖学框架

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摘要

A minimum amount of energy is required for basic physiological processes, such as protein biosynthesis, thermoregulation, locomotion, cardiovascular function, and digestion. However, for reproductive function and survival of the species, extra energy stores are necessary. Production of sex hormones and gametes, pubertal development, pregnancy, lactation, and parental care all require energy reserves. Thus the physiological systems that control energy homeostasis and reproductive function coevolved in mammals to support both individual health and species subsistence. In this review, we aim to gather scientific knowledge produced by laboratories around the world on the role of the brain in integrating metabolism and reproduction. We describe essential neuronal networks, highlighting key nodes and potential downstream targets. Novel animal models and genetic tools have produced substantial advances, but critical gaps remain. In times of soaring worldwide obesity and metabolic dysfunction, understanding the mechanisms by which metabolic stress alters reproductive physiology has become crucial for human health.
机译:基本的生理过程(例如蛋白质生物合成,温度调节,运动,心血管功能和消化)需要最少的能量。然而,为了繁殖功能和物种的生存,需要额外的能量存储。性激素和配子的产生,青春期的发育,怀孕,哺乳和父母的照顾都需要能量储备。因此,控制能量动态平衡和生殖功能的生理系统在哺乳动物中共同进化,以支持个体健康和物种生存。在这篇综述中,我们旨在收集世界各地实验室产生的关于大脑在整合新陈代谢和繁殖中的作用的科学知识。我们描述了必不可少的神经网络,突出了关键节点和潜在的下游目标。新颖的动物模型和遗传工具取得了长足的进步,但仍然存在重大差距。在全世界肥胖和代谢功能异常急剧恶化的时期,了解代谢压力改变生殖生理的机制对人类健康至关重要。

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