Lung Vascular Targeting Using Antibody to Aminopeptidase P: CT-SPECT Imaging Biodistribution and Pharmacokinetic Analysis

摘要

Background/AimsAminopeptidase P (APP) is specifically enriched in caveolae on the luminal surface of pulmonary vascular endothelium. APP antibodies bind lung endothelium in vivo and are rapidly and actively pumped across the endothelium into lung tissue. Here we characterize the immunotargeting properties and pharmacokinetics of the APP-specific recombinant antibody 833c.