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Age at onset and life table risks in genetic counselling for Huntingtons disease.

机译:发病年龄和生命表存在亨廷顿氏病遗传咨询的风险。

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摘要

Age related genetic risk data for carrying the gene for Huntington's disease in relatives at risk, based on a previously documented life table approach, are presented in a form allowing ready access for use in genetic counselling. Figures are given for first degree relatives and for second degree relatives showing varying age combinations of consultand and intervening parent at risk. Data are also given for the risk of developing Huntington's disease over varying finite periods in relation to age. The availability of this information in tabular form should help those involved in genetic counselling for this disorder in providing accurate risk estimates to relatives; the data are also of importance for combination with genotype information in predictive testing.
机译:根据先前记录的生命表方法,以可随时访问的形式提供了与年龄相关的遗传风险数据,用于在处于风险的亲戚中携带亨廷顿氏病基因。给出了一级亲属和二级亲属的数字,显示了受咨询者和有风险的父母中间年龄组合的变化。还提供了与年龄有关的有限有限时期内发生亨廷顿氏病风险的数据。以表格形式提供的这些信息应有助于参与该疾病遗传咨询的人员向亲属提供准确的风险估计;数据对于在预测测试中与基因型信息相结合也很重要。

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