Regional Brain Glucose Metabolism and Neurocognitive Function in Adult Survivors of Childhood Cancer Treated with Cranial Radiation

摘要

The objective of this study was to examine associations between regional brain metabolism, as measured by ¹⁸F-FDG PET, and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation.MethodThirty-eight adult survivors of ALL were randomly selected from a large cohort treated with cranial radiation therapy (19 with 18 Gy and 19 with 24 Gy of exposure). At a mean age of 26.4 (range, 22.3–37.4) years, and 23.5 (range, 20.4–32.8) years since diagnosis, patients underwent comprehensive neurocognitive evaluations and brain ¹⁸F-FDG PET imaging during a resting condition. ¹⁸F-FDG PET images were analyzed stereotactically, and pixel values were normalized to global activity. Predefined region-of-interest and voxel-based correlation analyses were performed.