Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

机译：克罗麦卡林前药1（CKLP1）对水液动力学的影响以及与现有降压药联合治疗的可行性

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摘要

PurposeCromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents.

机译：目的克罗麦卡林前药1（CKLP1）是一种水溶性ATP敏感的钾通道开放剂，在离体和体内实验模型中均显示出眼压下降的特性。为了确定其作用机理，我们评估了CKLP1对房水动力学的影响以及与现有眼部降压药联合治疗的效果。

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期刊名称 Investigative Ophthalmology Visual Science
作者
Uttio Roy Chowdhury; Tommy A. Rinkoski; Cindy K. Bahler; J. Cameron Millar; Jacques A. Bertrand; Bradley H. Holman; Joseph M. Sherwood; Darryl R. Overby; Kristen L. Stoltz; Peter I. Dosa; Michael P. Fautsch;
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作者单位

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年(卷),期 -1(58),13
年度 -1
页码 5731–5742
总页数 12
原文格式 PDF
正文语种
中图分类眼科学;
关键词
ATP-sensitive potassium channel intraocular pressure glaucoma medications distal outflow ocular hypertension;

机译：ATP敏感性钾通道;眼压;青光眼药物;远端流出;高眼压;

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1. Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents [J] . Uttio Roy Chowdhury, Tommy A. Rinkoski, Cindy K. Bahler, Investigative ophthalmology & visual science . 2017,第13期

机译：克罗麦卡林前药1（CKLP1）对水性幽默动力学的影响以及现有的降压药联合治疗的可行性
2. Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents [J] . Chowdhury Uttio Roy, Rinkoski Tommy A., Bahler Cindy K., Investigative ophthalmology & visual science . 2017,第13期

机译：Cromakalim Prodrug 1（CKLP1）对现有眼低血压试剂的幽默动力学和可行性的影响
3. Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener [J] . Fautsch Michael P., Kudgus Rachel, Rinkoski Tommy, Investigative ophthalmology & visual science . 2019,第9期

机译：眼睛降压剂Cromakalim前药1（CKLP1）的药理学和安全性，一种新型ATP敏感钾通道开启器
4. In-vivo luminescence model for the study of tumor regression and regrowth following combination regimens with differentiation-promoting agents and photodynamic therapy [C] . Rollakanti K, Anand S, Maytin EV Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXII . 2013

机译：体内发光模型用于研究分化促进剂和光动力疗法联合治疗后肿瘤的消退和再生长
5. An evaluation of NCRP report 151--radiation shielding design for radiotherapy facilities, and a feasibility study for 6 MV open-door treatments in an existing high-energy radiation therapy bunker. [D] . Kildea, John. 2010

机译：对NCRP报告151的评估-放射治疗设施的辐射屏蔽设计，以及在现有高能放射治疗掩体中进行6 MV开门治疗的可行性研究。
6. Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits [O] . Uttio Roy Chowdhury, Rachel A. Kudgus, Tommy A. Rinkoski, 2020

机译：荷兰腰带色素兔新型眼睛低压前药CKLP1的药理和药代动力学谱
7. Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents. [O] . Roy Chowdhury, U, Rinkoski, TA, Bahler, CK, 2017

机译：Cromakalim前药1（CKLp1）对现有眼压低血压药物水平动力学和联合治疗可行性的影响。
8. Studies of Ocular Complications of AIDS (SOCA): Database Documentation for'Combination Foscarnet and Ganciclovir Therapy versus Monotherapy for the Treatment of Relapsed Cytomegalovirus Retinitis in Patients with AIDS (CRRT)' [R] . 1997

机译：艾滋病眼部并发症（sOCa）研究：“联合膦甲酸和更昔洛韦治疗与单药治疗艾滋病患者复发性巨细胞病毒性视网膜炎（CRRT）”的数据库文件

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

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