A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap

机译：视网膜下基质胶大鼠脉络膜新生血管（CNV）模型和VEGF陷阱抑制CNV和相关的炎症和纤维化。

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摘要

Purpose.The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). A subretinal Matrigel (BD Biosciences, Bedford MA) model of CNV is described here, along with the effects of vascular endothelial growth factor (VEGF) neutralization on the development of CNV and associated inflammation and fibrosis.

机译：目的：与年龄相关的黄斑变性（AMD）的渗出性或湿性形式的特征是脉络膜新血管形成（CNV）。本文描述了CNV的视网膜下基质胶（BD Biosciences，Bedford MA）模型，以及血管内皮生长因子（VEGF）中和对CNV的发展以及相关炎症和纤维化的影响。

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期刊名称 Investigative Ophthalmology Visual Science
作者
Jingtai Cao; Lian Zhao; Yiwen Li; Yang Liu; Weihong Xiao; Ying Song; Lingyu Luo; Deqiang Huang; George D. Yancopoulos; Stanley J. Wiegand; Rong Wen;
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作者单位

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年(卷),期 -1(51),11
年度 -1
页码 6009–6017
总页数 9
原文格式 PDF
正文语种
中图分类眼科学;
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专利

1. A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. [J] . Cao J, Zhao L, Li Y, Investigative ophthalmology & visual science . 2010,第11期

机译：视网膜下基质胶大鼠脉络膜新血管形成（CNV）模型，并通过VEGF捕集器抑制CNV及其相关的炎症和纤维化。
2. Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model [J] . Will-Orrego Adrian, Liao Sha-Mei, Qiu Yubin, Investigative ophthalmology & visual science . 2016,第12期

机译：全身VEGF抑制在鼠激光诱导的脉络膜新生血管（CNV）模型中不调节眼部炎症细胞浸润
3. Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model [J] . Oscar Olvera-Monta?o, Leopoldo Baiza-Duran, Juan D Quintana-Hau, Drug Design, Development and Therapy . 2019,第1期

机译：比较抗人VEGF-A中和抗体对激光诱导的脉络膜新生血管（CNV）恒河猴模型的疗效
4. Improved Covering Blanket method for Choroidal Neovascularization (CNV) texture quantification [C] . Anil R. Lande, Sangameshwar S. Pendalwar, Sandeep V. Paranjape IEEE International Conference on Electronics, Computing and Communication Technologies . 2015

机译：改进的覆盖毯方法用于脉络膜新血管形成（CNV）纹理量化
5. A model for choroidal neovascularization (CNV) and gene therapy for age-related macular degeneration (AMD). [D] . Wang, Fei. 2001

机译：脉络膜新生血管（CNV）和年龄相关性黄斑变性（AMD）基因治疗的模型。
6. Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model [O] . Oscar Olvera-Montaño, Leopoldo Baiza-Duran, Juan D Quintana-Hau, 2019

机译：比较抗人VEGF-A中和抗体与贝伐单抗在激光诱导的脉络膜新血管形成（CNV）恒河猴模型上的功效
7. A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap [O] . Cao, Jingtai, Zhao, Lian, Li, Yiwen, 2010

机译：视网膜下基质胶大鼠脉络膜新生血管（CNV）模型和VEGF陷阱抑制CNV和相关的炎症和纤维化。

A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap

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