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Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

机译：由于ABCA1丢失导致胰岛胆固醇积聚导致胰岛素颗粒的胞吐功能受损。

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OBJECTIVEThe ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ABCA1.

机译：目的ATP结合盒转运蛋白A1（ABCA1）对于β细胞正常分泌胰岛素至关重要。这项研究的目的是阐明缺乏β细胞ABCA1的胰岛中胰岛素分泌受损的潜在机制。

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期刊名称 Diabetes
作者
Janine K. Kruit; Nadeeja Wijesekara; Jocelyn E. Manning Fox; Xiao-Qing Dai; Liam R. Brunham; Gavin J. Searle; Garry P. Morgan; Adam J. Costin; Renmei Tang; Alpana Bhattacharjee; James D. Johnson; Peter E. Light; Brad J. Marsh; Patrick E. MacDonald; C. Bruce Verchere; Michael R. Hayden;
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年(卷),期 2011(60),12
年度 2011
页码 3186–3196
总页数 11
原文格式 PDF
正文语种
中图分类基础医学;
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专利

1. Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules [J] . Janine K. Kruit, Nadeeja Wijesekara, Jocelyn E. Manning Fox, Diabetes . 2011,第12期

机译：由于ABCA1丢失导致胰岛胆固醇积聚导致胰岛素颗粒的胞吐功能受损。
2. MiR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets [J] . Nadeeja Wijesekara, Lin-hua Zhang, Martin H. Kang, Diabetes . 2012,第3期

机译：MiR-33a调节胰岛中的ABCA1表达，胆固醇蓄积和胰岛素分泌
3. Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells [J] . Lyu Jingya, Imachi Hitomi, Fukunaga Kensaku, Journal of Lipid Research . 2018,第10期

机译：血管紧张素II通过调节β细胞中的ABCA1诱导胆固醇积累并损害胰岛素分泌
4. Arsenic impaired cholesterol efflux by inhibiting ABCA1 and ABCG1 [C] . Z. Yuan, X.H. Tan, X.L.Xu, International Congress on Arsenic in the Environment . 2016

机译：通过抑制ABCA1和ABCG1，砷抑制胆固醇流出
5. Single cell assay of secretion using membrane capacitance measurements: The modulation of calcium-triggered insulin granule exocytosis by cyclic 3'-5'-adenosine monophosphate [D] . Gillis, Kevin David 1993

机译：使用膜电容测量的分泌单细胞测定：环状3'-5'-腺苷一磷酸调节钙触发的胰岛素颗粒胞吐作用
6. miR-33a Modulates ABCA1 Expression Cholesterol Accumulation and Insulin Secretion in Pancreatic Islets [O] . Nadeeja Wijesekara, Lin-hua Zhang, Martin H. Kang, 2012

机译：miR-33a调节胰岛中的ABCA1表达胆固醇蓄积和胰岛素分泌
7. Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules [O] . Michael R. Hayden 2016

机译：由于aBCa1缺失导致胰岛胆固醇累积导致胰岛素颗粒的胞吐作用受损

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

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