A Clinical and Radiographic Evaluation of PeriodontalRegenerative Potential of PerioGlas®: A Synthetic ResorbableMaterial in Treating Periodontal Infrabony Defects

摘要

>Background: Study of the clinical application of bioactive glass in treating periodontal defects has been gaining momentum. Studies in the past have hypothesized that bioactive glass resulted in an improvement of bony lesion when compared with open flap debridement. Considering that there were very few studies in the Indian dental literature involving the analysis of PerioGlas®- A particulate Bioglass in intrabony defects, the present clinical trial aimed to clinically and radiographically evaluate the efficacy of PerioGlas® and compare it to open debridement as control in the treatment of human periodontal osseous (three and two wall) defects in South Indian population. >Materials and Methods: Ten patients with chronic periodontitis within the age group of 30-45 years having at least two pockets with depth of ≥6 mm exhibiting vertical osseous defects were selected for the study. Atotal of 20 defect sites were randomly assigned to one of the twotreatment modalities such that 10 sites (experimental) receivedPerioGlas® material after open flap debridement and 10 sites withopen flap debridement (controls). Plaque index and gingival index(GI) were recorded at baseline, 6 weeks, 3 months, 6 months and 9months, whereas probing pocket depth (PPD), clinical attachmentlevel and gingival recession (GR) were recorded at baseline, 6 and9 months postoperatively. Linear radiographic measurements werecarried out at baseline, 6 and 9 months to evaluate the defectfill, defect resolution and change in the alveolar crest height(ACH).>Results:Both experimental and control site showed a significant reductionin plaque and GI, and a slight increase in GR. The mean reductionin PPD for experimental and control site was 4.4 ± 0.34 mm and 3.2± 0.1 mm, respectively. Gain in clinical attachment at experimentaland control site was 4.4 ± 0.21 and 3.4 ± 0.11, respectively whichon comparison was statistically non-significant for both sites. Theradiographic mean defect fill for experimental site was 1.73 mm.The mean defect resolution was 46.5% and 15.3% for the experimentalgroup and control group, respectively, with a slight increase inthe ACH at the experimental site.>Conclusion:Comparison of experimental and control sites revealed astatistically significant improvement in both clinical andradiographic parameters, but experimental sites showed betterresults when compared with control.>How to cite the article:Chacko NL, Abraham S, Rao HN, Sridhar N, Moon N, Barde DH. Aclinical and radiographic evaluation of periodontal regenerativepotential of PerioGlas®: A synthetic, resorbable material intreating periodontal infrabony defects. J Int Oral Health2014;6(3):20-6.