Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels

摘要

AimsAlthough several cultured endothelial cell studies indicate that sphingosine-1-phosphate (S1P), via GTPase Rac1 activation, enhances endothelial barriers, very few in situ studies have been published. We aimed to further investigate the mechanisms whereby S1P modulates both baseline and increased permeability in intact microvessels.