Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress improve mitochondrial function and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

摘要

BackgroundSepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and oxidative stress. We investigated the effects of treatment with antioxidants that protect mitochondria (MitoQ, MitoE, or melatonin) in a rat model of lipopolysaccharide (LPS) plus peptidoglycan (PepG)-induced acute sepsis, characterized by inflammation, mitochondrial dysfunction and early organ damage.