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A cell-based high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists

机译：基于细胞的高通量均相时间分辨荧光测定法用于筛选潜在的κ阿片受体激动剂

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摘要

Aim:The aim of this study was to identify κ-opioid receptor (KOR) agonists from a library of 80 000 small-molecule compounds and provide the experimental basis for the development of new analgesic candidates.

机译：目的：本研究的目的是从一个包含8万种小分子化合物的文库中鉴定κ阿片受体（KOR）激动剂，并为开发新型镇痛药提供实验依据。

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期刊名称 Acta Pharmacologica Sinica
作者
Yue Wang; Ming Yan; Guang-yao Zheng; Ling He; Huan Yang;
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作者单位

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年(卷),期 2014(35),7
年度 2014
页码 957–966
总页数 10
原文格式 PDF
正文语种
中图分类药学;
关键词
κ-opioid receptor agonists LANCEsup™/sup cAMP assay high-throughput screening structure-activity relationship writhing test;

机译：κ阿片受体激动剂;LANCE sup™/ sup cAMP测定;高通量筛选;构效关系;扭曲试验;

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专利

1. A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists [J] . Yue WANG, Ming YAN, Guang-yao ZHENG, 中国药理学报：英文版 . 2014,第007期

机译：基于细胞的高通量均相时间分辨荧光测定法，用于筛选潜在的κ阿片受体激动剂
2. A novel cell-based duplex high-throughput screening assay combining fluorescent Ca2+ measurement with homogeneous time-resolved fluorescence technology [J] . Kiss Laszlo, Cselenyak Attila, Varga Agnes, Analytical Biochemistry: An International Journal of Analytical and Preparative Methods . 2016,第Null期

机译：一种新颖的基于细胞的双重高通量筛选测定方法，将荧光钙离子测量与均相时间分辨荧光技术相结合
3. A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase [J] . Stowell Alexandra I. J., James Dominic I., Waddell Ian D., Analytical Biochemistry: An International Journal of Analytical and Preparative Methods . 2016,第Null期

机译：测量人聚（ADP-核糖）甘油糖酶的甘油化酶活性的高通量筛选相容性均相分辨荧光测定
4. Identification of opioid receptor ligand interactions using structurally related delta-opioid receptor agonists and antagonists and molecular modeling. [C] . Sharon D.Bryant, Yunden Jinsmaa, Lawrence H.Lazarus International Peptide Symposium;European Peptide Symposium . 2005

机译：使用结构相关的δ-阿片类受体激动剂和拮抗剂和分子建模鉴定阿片受体配体的相互作用。
5. Development of a cell-based high-throughput screening assay with podocytes. [D] . Hays, Tristan T. 2014

机译：基于细胞的足细胞高通量筛选检测方法的开发。
6. A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E–receptor interactions [O] . Beomkyu Kim, Svetlana S. Tarchevskaya, Alexander Eggel, -1

机译：适用于免疫球蛋白E-受体相互作用抑制剂的高通量筛选的时间分辨荧光共振能量传递测定
7. A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists [O] . Yue Wang, Ming Yan, Guang-yao Zheng, 2014

机译：用于筛选电位κ-阿片受体激动剂的细胞基，高通量均相分辨荧光测定

A cell-based high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists

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