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Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro

机译：鞘氨醇-1-磷酸在体外内皮细胞中通过MMP-2 / FGF-1 / FGFR-1依赖性途径诱导VEGF-C表达

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摘要

Aim:To investigate whether sphingosine-1-phosphate (S1P), a potent angiogenic factor, induced vascular endothelial growth factor-C (VEGF-C) expression in endothelial cells in vitro and to examine its underlying mechanisms.

机译：目的：研究鞘氨醇-1-磷酸（S1P）（一种有效的血管生成因子）是否在体外诱导了内皮细胞中血管内皮生长因子-C（VEGF-C）的表达，并探讨了其潜在机制。

著录项

期刊名称 Acta Pharmacologica Sinica
作者
Chi-hao Chang; Yuan-li Huang; Ming-kwang Shyu; Shee-uan Chen; Chih-hsin Lin; Tsai-kai Ju; JenHer Lu; Hsinyu Lee;
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作者单位

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年(卷),期 2013(34),3
年度 2013
页码 360–366
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
sphingosine-1-phosphate VEGF-C matrix metalloproteinase-2 fibroblast growth factor-1 fibroblast growth factor receptor-1 GM6001 SU5402 transactivation human umbilical vein endothelial cells RNA interference;

机译：鞘氨醇-1-磷酸;VEGF-C;基质金属蛋白酶-2;成纤维细胞生长因子-1;成纤维细胞生长因子受体-1;GM6001;SU5402;反式激活;人脐静脉内皮细胞;RNA干扰;

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专利

1. Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro [J] . Chi-hao CHANG, Yuan-li HUANG, Ming-kwang SHYU, 中国药理学报：英文版 . 2013,第003期

机译：鞘氨醇-1-磷酸在体外内皮细胞中通过MMP-2 / FGF-1 / FGFR-1依赖性途径诱导VEGF-C表达
2. Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-γ-Inducible Protein of 10 kDa In Vitro and In Vivo [J] . Gwénola Boulday, Zdenka Haskova, Marlies E. J. Reinders, The journal of immunology . 2006,第5期

机译：血管内皮生长因子诱导的内皮细胞介导趋化因子IFN-γ诱导的10 kDa体内和体外蛋白质过度表达的信号通路。
3. Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa in vitro and in vivo. [J] . Boulday G, Haskova Z, Reinders ME, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第5期

机译：内皮细胞中血管内皮生长因子诱导的信号转导通路，在体内外介导10 kDa趋化因子IFN-γ诱导蛋白的过表达。
4. Reversal of Hyperglycemia-Induced Angiogenesis Deficit of Human Endothelial Cells by Over expression of Glyoxalase 1 In Vitro [C] . USMAN AHMED, DARIN DOBLER, SARAH J. LARKIN, International Symposium on the Maillard Reaction . 2008

机译：通过对乙醛酸酶1体外表达逆血糖诱导的高血糖诱导的血管生成血管生成缺损
5. Effects of folate deficiency on endothelial cell biology: Folate deficiency induces profound effects on global patterns of gene expression in vascular endothelial cells. [D] . Khorana, Radhika. 2006

机译：叶酸缺乏对内皮细胞生物学的影响：叶酸缺乏对血管内皮细胞基因表达的整体模式产生深远影响。
6. TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells [O] . Hongyan Zhu, Rongrong Dai, Youquan Zhou, -1

机译：TLR2配体Pam3CSK4通过MAPK /NF-κB信号通路调节人脑微血管内皮细胞中MMP-2 / 9的表达
7. Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro [O] . Chi-hao Chang, Yuan-li Huang, Ming-kwang Shyu, 2013

机译：鞘氨酸-1-磷酸盐通过在体外中内皮细胞中的MMP-2 / FGF-1 / FGFR-1依赖性途径诱导VEGF-C表达
8. Characterization of Freeze-Thaw Induced Ultrastructural Damage to Endothelial Cells in Vitro [R] . Trusal, L. R., Guzman, A. W., Baker, C. J. 1984

机译：冻融诱导内皮细胞体外超微结构损伤的表征

Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro

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