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Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

机译：丹参酮IIA磺酸钠通过激活PI3K / Akt / FOXO3A / Bim途径保护大鼠心肌免受缺血再灌注损伤

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摘要

Aim:To investigate the mechanisms underlying the protective effects of sodium tanshinone IIA sulfonate (STS) in an ischemia-reperfusion (I/R)-induced rat myocardial injury model.

机译：目的：探讨丹参酮IIA磺酸钠（STS）在缺血/再灌注（I / R）诱导的大鼠心肌损伤模型中的保护作用的潜在机制。

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期刊名称 Acta Pharmacologica Sinica
作者
Mei-qi Zhang; Yue-liang Zheng; Huan Chen; Jian-feng Tu; Ye Shen; Jun-ping Guo; Xiang-hong Yang; Shu-ren Yuan; Liang-zhong Chen; Jing-jie Chai; Jian-hong Lu; Chang-lin Zhai;
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年(卷),期 2013(34),11
年度 2013
页码 1386–1396
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
sodium tanshinone IIA sulfonate heart attack myocardial ischemia-reperfusion apoptosis Akt FOXO3a Bim PI3K;

机译：丹参酮IIA磺酸钠;心脏病发作;心肌缺血再灌注;凋亡;Akt;FOXO3a;Bim;PI3K;

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专利

1. Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway [J] . Mei-qi ZHANG, Yue-liang ZHENG, Huan CHEN, 中国药理学报：英文版 . 2013,第011期

机译：丹参酮IIA磺酸钠可通过激活PI3K / Akt / FOXO3A / Bim途径保护大鼠心肌免受缺血再灌注损伤
2. Tanshinone IIA protects against myocardial ischemia reperfusion injury by activating the PI3K/Akt/mTOR signaling pathway [J] . Li Qiang, Shen Li, Wang Zhen, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2016,第Null期

机译：丹参酮IIA通过激活PI3K / Akt / mTOR信号通路来预防心肌缺血再灌注损伤
3. Tanshinone IIA protects against myocardial ischemia reperfusion injury by activating the PI3K/Akt/mTOR signaling pathway [J] . Li Qiang, Shen Li, Wang Zhen, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2016,第Null期

机译：丹参酮IIA通过激活PI3K / AKT / MTOR信号通路来保护心肌缺血再灌注损伤
4. Preparation, Characterization evaluation of Tanshinone IIA lipid microspere and comparative study of pharmacokinetics with Sodium Tanshinone IIA Sulfonate injection [C] . Xinli Liang, Mengliang Zhu, Yunchao Cao International Conference on Chemical Engineering and Advanced Materials . 2013

机译：丹参酮脂质微孔的制备，表征评价及药代动力学对丹参酮IIA磺酸钠注射液的比较研究
5. Total Ginsenosides of Asian Ginseng Increase Coronary Artery Perfusion Flow of the Ischemia-Reperfusion Injury Rat Heart in Langendorff System through Activation of Akt-eNOS Signaling and Cardiac Energy-associate Protein Expression. [D] . Yi, Xiaoqin. 2010

机译：亚洲人参的总人参皂甙通过激活Akt-eNOS信号和心脏能量相关蛋白表达，增加Langendorff系统缺血再灌注损伤大鼠心脏的冠状动脉灌注流量。
6. Tanshinone IIA protects mice against atherosclerotic injury by activating the TGF-β/PI3K/Akt/eNOS pathway [O] . Junyan Wang, Xinyong He, Wenna Chen, -1

机译：丹参酮IIA通过激活TGF-β/ PI3K / Akt / eNOS途径保护小鼠免受动脉粥样硬化损伤
7. Tanshinone IIAnbsp;Combined With CsAnbsp;Inhibit Myocardial Cell Apoptosis Induced by Renal Ischemia-reperfusion Injury by Modulating Mitochondrial Function Through PI3K/Akt/Bad Pathway in Obese Ratsnbsp; [O] . He Tai, Xiao-lin Jiang, Yue Li, 2020

机译：丹参酮联合CSA，通过在肥胖大鼠中通过PI3K / AKT /不良途径调节线粒体函数来抑制由肾缺血再灌注损伤诱导的心肌细胞凋亡

Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

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