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A Bioinformatics Practicum to Develop Student Understanding of Immunological Rejection of Protein Drugs

机译:一种生物信息学实践旨在培养学生对蛋白质药物免疫排斥的理解

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摘要

>Objectives. To design and implement a bioinformatics exercise that applies immunological principles to predicting rejection of protein drugs based upon patient genotype.>Design. Doctor of pharmacy (PharmD) students used the Immune Epitope Database, a freely available bioinformatics tool. Over a 2-week laboratory, students interrogated whether a protein drug would be predicted to induce an immune response based upon patient genotype. Results were presented at the last laboratory session, and students completed reports discussing their findings.>Assessment. Pre-lab quizzes and a final report were graded. Students answered questionnaires assessing perceived learning gains. To determine the impact on student understanding of immunity against protein drugs, the quality of student data analysis and comparisons to class data were graded. Independent measures of student learning demonstrated that students developed a greater understanding of how patient genotype could contribute to treatment failure with protein drugs.>Conclusions. This study indicates that questions related to clinical immunology can be posed using bioinformatics tools.
机译:>目标。要设计和实施一项生物信息学练习,该练习运用免疫学原理根据患者的基因型预测蛋白质药物的排斥反应。>设计。药学博士(PharmD)的学生使用了免疫功能Epitope数据库,可免费获得的生物信息学工具。在为期2周的实验室中,学生们根据患者的基因型询问是否可以预测蛋白质药物会诱导免疫反应。结果在上一堂实验中提出,学生们完成了讨论他们的发现的报告。>评估。对实验前测验和最终报告进行了评分。学生回答了问卷,评估了学习的收获。为了确定对学生对蛋白质药物免疫的理解的影响,对学生数据分析和与班级数据进行比较的质量进行了分级。独立的学生学习措施表明,学生对患者基因型如何导致蛋白药物治疗失败有了更深入的了解。>结论。。这项研究表明,可以使用生物信息学工具提出与临床免疫学有关的问题。

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