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Bezafibrate induced rhabdomyolysis.

机译:苯扎贝特引起横纹肌溶解。

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摘要

The case is presented of a 70 year old woman with mild hypercholesterolaemia and hypertension who was readmitted to hospital six months after a previous admission for angina pectoris. The patient was treated with verapamil, nifedipine, and aspirin, and had been receiving bezafibrate (400 mg every 12 hours) for the previous 40 days. Twenty four hours after admission she developed podagra, which was treated with indomethacin (100 mg daily). Eight days after admission myocardial infarction was suspected, and the next day she presented with symptoms of rhabdomyolysis, which was confirmed by laboratory tests. Bezafibrate was withdrawn and the patient became asymptomatic after seven days. It is recommended that doctors should be aware of the possibility of patients, especially those with impaired renal function, developing rhabdomyolysis while being treated with bezafibrate.
机译:该病例为一名70岁轻度高胆固醇血症和高血压的妇女,该妇女在先前因心绞痛入院六个月后再次入院。该患者接受维拉帕米,硝苯地平和阿司匹林治疗,并且在过去40天内一直接受苯扎贝特(每12小时400毫克)治疗。入院后二十四小时,她患上了podagra,并用吲哚美辛(每天100 mg)治疗。入院八天后怀疑有心肌梗塞,第二天她出现横纹肌溶解症状,经实验室检查证实。停用苯扎贝特,患者在7天后无症状。建议医生注意患者(尤其是肾功能受损的患者)接受苯扎贝特治疗时发生横纹肌溶解的可能性。

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