OBJECTIVE: To examine relationships between blood pressure during childhood and both placental weight and body size at birth, in an Australian population. DESIGN: A follow up study of a birth cohort, undertaken when cohort members were aged 8 years. SETTING: Adelaide, South Australia. SUBJECTS: 830 children born in the Queen Victoria Hospital in Adelaide, South Australia, during 1975-6. MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure measured when the children were aged 8 years. RESULTS: Blood pressure at 8 years was positively related to placental weight and inversely related to birth weight, after adjusting for the child's current weight. For diastolic pressure there was a decrease of 1.0 mm Hg for each 1 kg increase in birth weight (95% confidence interval (CI) = -0.4 to 2.4) and an increase of 0.7 mm Hg for each 100 g increase in placental weight (95% CI = 0.1 to 1.3). Diastolic pressure was also inversely related to chest circumference at birth, independently of placental weight, with a decrease of 0.3 mm Hg for each 1 cm increase in chest circumference (95% CI = 0.2 to 0.5). CONCLUSIONS: These findings are further evidence that birth characteristics, indicative of fetal growth patterns, are related to blood pressure in later life.
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机译：目的：探讨澳大利亚人群中儿童期血压与出生时胎盘重量和体重之间的关系。设计：队列研究对象的队列研究是在队列成员8岁时进行的。地点：南澳大利亚州阿德莱德。受试者：1975-6年间，在南澳大利亚州阿德莱德的维多利亚女王医院出生的830名儿童。主要观察指标：测量儿童8岁时的收缩压和舒张压。结果：在调整了孩子的当前体重之后，8岁时的血压与胎盘重量呈正相关，与出生体重呈负相关。对于舒张压，出生体重每增加1 kg汞柱，则降低1.0 mm Hg（95％置信区间（CI）= -0.4至2.4），胎盘重量每增加100 g，汞柱升高0.7 mm Hg（95 ％CI = 0.1至1.3）。舒张压也与出生时的胸围呈负相关，与胎盘重量无关，胸围每增加1 cm时，其舒张压下降0.3 mm Hg（95％CI = 0.2至0.5）。结论：这些发现进一步证明了出生特征，指示胎儿的生长方式，与以后的血压有关。
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