Expression and regulation of prostaglandin transporters ATP-binding cassette subfamily C member 1 and 9 and solute carrier organic anion transporter family member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs

摘要

ObjectiveProstaglandins (PGs) function in various reproductive processes, including luteolysis, maternal pregnancy recognition, conceptus development, and parturition. Our earlier study has shown that PG transporters ATP-binding cassette, subfamily C, member 4 (ABCC4) and solute carrier organic anion transporter family, member 2A1 (SLCO2A1) are expressed in the uterine endometrium in pigs. Since several other PG transporters such as ABCC1, ABCC9, SLCO4C1, and SLCO5A1 are known to be present in the uterine endometrium, this study investigated the expression of these PG transporters in the porcine uterine endometrium and placenta.