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Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

机译：先天性黄疸耿氏大鼠肝脏中特定细胞色素P-450同工酶的增加。

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摘要

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

机译：先天性黄疸（jj）大鼠比非黄疸（jj）大鼠的细胞色素P-450同工酶P-450c的肝微粒体含量更高。在jj和Jj大鼠之间，未发现P-450b，P-450d和孕烯醇酮-16α-甲腈诱导（PCN）P-450含量的差异。这是与遗传缺陷相关的特定细胞色素P-450同工酶组成型增加的首次证明。

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期刊名称 Biochemical Journal
作者
J Kapitulnik; J P Hardwick; J D Ostrow; C C Webster; S S Park; H V Gelboin;
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年(卷),期 1987(242),1
年度 1987
页码 297–300
总页数 4
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats [J] . C C Webster, H V Gelboin, J D Ostrow, The biochemical journal . 1987,第1期

机译：先天性黄疸耿氏大鼠肝脏中特定细胞色素P-450同工酶的增加
2. Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Female; Humans; Hydroxylation; Isoenzymes; Male; Membrane Proteins; Microsomes, Liver; Mixed Function Oxygenases; Pyrans; Rats; Rats, Wistar; Species Specificity [J] . La Medicina del lavoro . 2009,第4期

机译：动物;芳基烃羟化酶;细胞色素P-450 CYP3A;女;人类;羟基化;同工酶;男;膜蛋白;微粒体，肝脏;混合功能加氧酶;吡喃;大鼠;大鼠，Wistar;物种特异性
3. Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies. [J] . C De Lemos-Chiarandini, A B Frey, D D Sabatini, Journal of cell biology . 1987,第2期

机译：使用位点特异性抗体测定苯巴比妥诱导的大鼠肝细胞色素P-450同工酶PB-4的膜拓扑结构。
4. Increasing lesion specificity with fusion of manually and automatically segmented liver MR images [C] . Saim Ervural, Murat Ceylan Signal Processing and Communications Applications Conference . 2018

机译：通过融合手动和自动分割的肝脏MR图像来提高病变特异性
5. The active site structure and the substrate specificity of cytochrome P-450(cam). [D] . Atkins, William Mark. 1988

机译：细胞色素P-450（cam）的活性位点结构和底物特异性。
6. Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies [O] . 1987

机译：使用位点特异性抗体测定苯巴比妥诱导的大鼠肝细胞色素P-450同工酶PB-4的膜拓扑
7. Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats. [O] . Kapitulnik, J, Hardwick, J P, Ostrow, J D, 1987

机译：先天性黄疸耿氏大鼠肝脏中特定细胞色素P-450同工酶的增加。
8. Molecular dynamics simulations of norcamphor-cytochrome P-450(sub cam) and mutations of P-450(sub cam) designed to alter the product specificity. [R] . M. B. Bass M. D. Paulsen R. L. Ornstein 1991

机译：norcamphor-cytochrome p-450（sub cam）的分子动力学模拟和p-450（sub cam）的突变旨在改变产品特异性。

Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

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