Molecular dynamics simulations of norcamphor-cytochrome P-450(sub cam) and mutations of P-450(sub cam) designed to alter the product specificity.

摘要

Molecular dynamics simulations were performed to investigate the possibility of altering the product specificity of cytochrome P-450(sub cam). The design aims were to alter the product ratios of norcamphor to yield predominately 3-hydroxynorcamphor and to ...