MODIFIED CYTOCHROME P-450_cam OF MONOOXYGENASE (VARIANTS), METHOD OF OXIDATION OF COMPOUND TAKEN FROM GROUP CONTAINING POLYCYCLIC AROMATIC HYDROCARBON, LINEAR OR BRANCHED ALKANE, DIPHENYL OR BIPHENYL COMPOUND INCLUDING HALOGEN DERIVATIVES AND HYDROGEN HALIDES

摘要

FIELD: biochemistry, enzymes. SUBSTANCE: invention relates to the modified cytochrome P-450_cam where tyrosine residue at position 96 is substituted with any amino acid residue. Amino acid residues can be substituted additionally at least at one of positions 87, 98, 185, 244, 247, 295 and 298. Modification ensures to use cytochrome P-450_cam as a catalyst for oxidation of polycyclic aromatic hydrocarbons, linear or branched alkanes, diphenyl and biphenyl compounds including halogen derivatives and halogenated hydrocarbons also. EFFECT: enhanced effectiveness of cytochrome, improved method of oxidation. 9 cl, 3 dwg, 18 tbl