In vivo tracking of human placenta derived mesenchymal stem cells in nude mice via14C-TdR labeling

摘要

BackgroundIn order to shed light on the regenerative mechanism of mesenchymal stem cells (MSCs) in vivo, the bio-distribution profile of implanted cells using a stable and long-term tracking method is needed. We herein investigated the bio-distribution of human placental deciduas basalis derived MSCs (termed as PDB-MSCs) in nude mice after intravenous injection by carbon radioisotope labeling thymidine (¹⁴C-TdR), which is able to incorporate into new DNA strands during cell replication.