The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease

摘要

BackgroudIL-17⁺ T helper cells and Foxp3⁺ regulatory T cells are CD4⁺ T helper cells with reciprocally regulated differentiation and function. Their frequency and function vary in patients with chronic hepatitis B. In this study, we investigated the balance between IL-17⁺ T cells and Foxp3⁺ regulatory T cells and illustrated their function in the aggravation of chronic hepatitis B (CHB).