Next-generation sequencing identifies monogenic diabetes in 16 of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

摘要

BackgroundMonogenic diabetes (MgD) accounts for 1–2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical suspicion of MgD.