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Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry

机译：车花酸和punicalagin对使用糖胺聚糖进入的病毒的广谱抗病毒活性

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BackgroundWe previously identified two hydrolyzable tannins, chebulagic acid (CHLA) and punicalagin (PUG) that blocked herpes simplex virus type 1 (HSV-1) entry and spread. These compounds inhibited viral glycoprotein interactions with cell surface glycosaminoglycans (GAGs). Based on this property, we evaluated their antiviral efficacy against several different viruses known to employ GAGs for host cell entry.

机译：背景我们之前确定了两种可水解的丹宁酸，Chebulagic acid（CHLA）和punicalagin（PUG），它们阻止了1型单纯疱疹病毒（HSV-1）的进入和扩散。这些化合物抑制病毒糖蛋白与细胞表面糖胺聚糖（GAGs）的相互作用。基于此属性，我们评估了它们对几种已知利用GAG进入宿主细胞进入的不同病毒的抗病毒效力。

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期刊名称 BMC Microbiology
作者
Liang-Tzung Lin; Ting-Ying Chen; Song-Chow Lin; Chueh-Yao Chung; Ta-Chen Lin; Guey-Horng Wang; Robert Anderson; Chun-Ching Lin; Christopher D Richardson;
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作者单位

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年(卷),期 2013(13),-1
年度 2013
页码 187
总页数 15
原文格式 PDF
正文语种
中图分类微生物学;
关键词
Chebulagic acid Punicalagin Tannin Broad-spectrum antivirals Viral entry Glycosaminoglycans;

机译：车花酸;葛根素;单宁;广谱抗病毒药;病毒进入;糖胺聚糖;

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专利

1. Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry [J] . Liang-Tzung Lin, Ting-Ying Chen, Song-Chow Lin, BMC Microbiology . 2013,第1期

机译：车花酸和punicalagin对使用糖胺聚糖进入的病毒的广谱抗病毒活性
2. Broad-Spectrum Antiviral Activity of Nucleic Acid-Based Antiviral Agents Against Avian and Seasonal Influenza Viruses [J] . J.P.Wong, M.E.Christopher, L.Q.Sun, International journal of infectious diseases : . 2008,第Supplementa1期

机译：基于核酸的抗病毒药物对禽流感和季节性流感病毒的广谱抗病毒活性
3. A broad-spectrum antiviral targeting entry of enveloped viruses [J] . Mike C. Wolf, Alexander N. Freiberg, Tinghu Zhang, Proceedings of the National Academy of Sciences of the United States of America . 2010,第7期

机译：针对包膜病毒进入的广谱抗病毒
4. Anti-HIV, Anti-Poxvirus, and Anti-SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet-V/anti-Vac Suggests That It Contains a Novel Broad-Spectrum Antiviral [C] . GIRISH J. KOTWAL, JENNIFER N. KACZMAREK, STEVEN LEIVERS, International Conference on Natural Products and Molecular Medicine . 2005

机译：来自Triforium-V / Anti-VAC的无毒，抗痘病毒和抗SARS活性的无毒，酸性植物提取物表明它含有一种新型广谱抗病毒
5. A novel broad-spectrum antiviral targeting entry of enveloped viruses. [D] . Wolf, Michael Christopher. 2009

机译：一种针对包膜病毒进入的新型广谱抗病毒药物。
6. Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread [O] . Liang-Tzung Lin, Ting-Ying Chen, Chueh-Yao Chung, 2011

机译：可水解的单宁酸（Chebulagic Acid和Punicalagin）靶向病毒糖蛋白-糖胺聚糖相互作用抑制单纯疱疹病毒1进入和细胞间传播
7. Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry [O] . 2013

机译：车花酸和punicalagin对使用糖胺聚糖进入的病毒的广谱抗病毒活性

Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry

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