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MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways

机译：MiR-139通过靶向GHR和IGF1R信号通路抑制牛乳腺上皮细胞中β-酪蛋白的合成和增殖

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摘要

BackgroundMicroRNAs have important roles in many biological processes. However, the role of miR-139 in healthy mammary gland remains unclear. The objective of this study was to investigate the effects of miR-139 on lactation in dairy cows.

机译：背景微小RNA在许多生物学过程中具有重要作用。但是，miR-139在健康乳腺中的作用尚不清楚。这项研究的目的是研究miR-139对奶牛泌乳的影响。

著录项

期刊名称 BMC Veterinary Research
作者
Yingjun Cui; Xia Sun; Lianfeng Jin; Guangpu Yu; Qingzhang Li; Xuejun Gao; Jinxia Ao; Chunmei Wang;
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作者单位

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年(卷),期 2017(13),-1
年度 2017
页码 350
总页数 10
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
miR-139 Mammary gland β-casein Growth hormone receptor Type I insulin-like growth factor receptor;

机译：miR-139;乳腺;β-酪蛋白;生长激素受体;I型胰岛素样生长因子受体;

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专利

1. MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways [J] . Yingjun Cui, Xia Sun, Lianfeng Jin, BMC Veterinary Research . 2017,第1期

机译：MiR-139通过靶向GHR和IGF1R信号通路抑制牛乳腺上皮细胞中β-酪蛋白的合成和增殖
2. Seryl-tRNA synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells [J] . Dai W. T., White R. R., Liu J. X., Journal of dairy science . 2018,第11期

机译：丝氨酰tRNA合成酶介导的必需氨基酸通过牛乳腺上皮细胞中的细胞增殖和雷帕霉素（mTOR）信号转导途径的哺乳动物靶标调节β-酪蛋白的合成
3. Short communication: Relationship between lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells [J] . F. Wang, J. van Baal, L. Ma, Journal of dairy science . 2019,第9期

机译：短期通信：赖氨酸/甲硫氨酸比与葡萄糖水平的关系及其对牛乳酰乳液上皮细胞雷帕霉素信号传导途径的机械靶标的对酪蛋白合成的影响
4. α-S1-casein (CSN1S1) suppresses β-casein expression via JAK2/STAT5a signaling pathway in goat mammary epithelial cells [C] . Ning Song, Jun Luo, Yating Chen The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：α-S1-酪蛋白（CSN1S1）通过JAK2 / Stat5a信号传导途径在山羊乳状上皮细胞中抑制β-酪蛋白表达
5. The mammalian target of rapamycin signaling pathway in bovine mammary epithelial cells. [D] . Burgos, Sergio A. 2010

机译：牛乳腺上皮细胞中雷帕霉素信号传导途径的哺乳动物靶标。
6. Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells [O] . Jianhua Sun, Juxiong Liu, Bingxu Huang, 2017

机译：Kisspeptin-10在牛乳腺上皮细胞中通过GPR54诱导β-酪蛋白合成及其下游信号通路。
7. Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells [O] . H.N. Gao, S.G. Zhao, N. Zheng, 2017

机译：组合，赖氨酸，蛋氨酸和亮氨酸的组合通过牛乳腺上皮细胞的雷帕霉素信号传导途径的机械靶促进β-酪蛋白合成
8. Analysis of Progestin Effects on Hepatocyte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morphogenesis of Normal Mammary Epithelial Cells in Vitro [R] . Smith, K. T. 2003

机译：孕激素对肝细胞生长因子信号通路的影响与体外正常乳腺上皮细胞增殖和肺泡形态发生的关系

MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways

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