Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor RHO ROCK and MLC2 to induce lymph endothelial barrier breaching

摘要

Background: The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive.