composition, methods for inhibiting vascular permeability, pathological angiogenesis, and one plus rac activation or availability, arf6 activation or availability, vascular leakage, vascular permeability, pathological angiogenesis, and signal inhibition of multiple angiogenic, permeability, and inflammatory factors, and methods for preserving endothelial barrier function, and for blocking vegf signaling downstream of the vegf receptor

摘要

Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis by modulating a signaling pathway delineated herein are described. Moreover, methods for producing and screening compounds and compositions capable of modulating the signaling pathway described herein, inhibiting vascular permeability, and inhibiting pathologic angiogenesis are also provided.