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Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial

机译：难治性癌症患者的随机概念验证第二阶段试验比较基于肿瘤分子轮廓分析和常规疗法的靶向治疗：SHIVA试验可行性部分的结果

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摘要

Background: The SHIVA trial is a multicentric randomised proof-of-concept phase II trial comparing molecularly targeted therapy based on tumour molecular profiling vs conventional therapy in patients with any type of refractory cancer. Results of the feasibility study on the first 100 enrolled patients are presented.

机译：背景：SHIVA试验是一项多中心的随机概念验证II期试验，比较了基于肿瘤分子特征分析的分子靶向疗法与常规疗法在任何类型的难治性癌症患者中的疗效。介绍了对前100名患者进行可行性研究的结果。

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期刊名称 British Journal of Cancer
作者
C Le Tourneau; X Paoletti; N Servant; I Bièche; D Gentien; T Rio Frio; A Vincent-Salomon; V Servois; J Romejon; O Mariani; V Bernard; P Huppe; G Pierron; F Mulot; C Callens; J Wong; C Mauborgne; E Rouleau; C Reyes; E Henry; Q Leroy; P Gestraud; P La Rosa; L Escalup; E Mitry; O Trédan; J-P Delord; M Campone; A Goncalves; N Isambert; C Gavoille; M Kamal;
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年(卷),期 2014(111),1
年度 2014
页码 17–24
总页数 8
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
feasibility molecular profile personalised medicine randomised study SHIVA sequencing;

机译：可行性;分子谱;个性化药物;随机研究;SHIVA;测序;

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专利

1. Randomized phase II trial comparing molecularly targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: cross-over analysis from the SHIVA trial [J] . Belin L., Kamal M., Mauborgne C., Annals of oncology: official journal of the European Society for Medical Oncology . 2017,第3期

机译：基于肿瘤分子分析的分子靶向治疗对难治性癌症患者的分子靶向治疗进行随机靶向治疗：Shiva试验的交叉分析
2. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial [J] . Le Tourneau Christophe, Delord Jean-Pierre, Goncalves Anthony, The lancet oncology . 2015,第13期

机译：基于肿瘤分子谱分析的分子靶向治疗与常规治疗晚期癌症（SHIVA）的分子靶向治疗：一项多中心，开放标签，概念验证，随机，对照的2期试验
3. The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage I non-small cell lung cancer (NSCLC) considered to be at higher risk of complications from surgical resection [J] . M. P. Snee, L. McParland, F. Collinson, Pilot and Feasibility Studies . 2016,第1期

机译：SABRTooth可行性试验方案：一项研究，用于确定在III期非小细胞肺癌（NSCLC）患者中进行立体定向消融放疗（SABR）与手术比较的III期随机对照试验的可行性和可接受性手术切除引起并发症的风险更高
4. Synbiotic Therapy Significantly Reduces Molecular Markers of Inflammation and Clinical Scores in Patients with Active Ulcerative Colitis; A Randomised Controlled Trial [C] . Controlled Release Society annual meeting . 2004

机译：同步治疗显着减少了活性溃疡性结肠炎患者的炎症和临床评分的分子标记;随机对照试验
5. Sexuality and gynaecological cancer: A randomised control trial to evaluate the effectiveness of a group psychoeducational intervention in improving the sexual health of women with gynaecological cancer treated with radiotherapy [D] . Jeffries, Sherryl Anne 2003

机译：性与妇科癌症：一项随机对照试验，旨在评估团体心理教育干预措施对经放射治疗的妇科癌症妇女改善性健康的有效性
6. The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage I non-small cell lung cancer (NSCLC) considered to be at higher risk of complications from surgical resection [O] . M. P. Snee, L. McParland, F. Collinson, 2016

机译：SABRTooth可行性试验方案：一项研究用于确定在III期非小细胞肺癌（NSCLC）患者中进行立体定向消融放疗（SABR）与手术比较的III期随机对照试验的可行性和可接受性手术切除并发症的风险更高
7. Erratum to: The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage I non-small cell lung cancer (NSCLC) considered to be at higher risk of complications from surgical resection [O] . M. P. Snee, L. McParland, F. Collinson, 2016

机译：勘误至：SABRTooth可行性试验方案：一项研究，用于研究在考虑的外周I期非小细胞肺癌（NSCLC）患者中进行立体定向消融放疗（SABR）与手术的比较的III期随机对照试验的可行性和可接受性手术切除并发症的风险较高

Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial

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