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Pharmacokinetics pharmacodynamics short term efficacy and safety of RCT‐18 a novel BLyS/APRIL fusion protein in patients with rheumatoid arthritis

机译：类风湿关节炎患者新型BLyS / APRIL融合蛋白RCT-18的药代动力学药效学短期疗效和安全性

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AimRCT‐18 is a recombinant fusion protein that interferes with the selection and survival of mature B‐lymphocytes by inhibiting B‐lymphocyte stimulator and a proliferation‐inducing ligand.

机译：AimRCT-18是一种重组融合蛋白，可通过抑制B淋巴细胞刺激剂和诱导增殖的配体来干扰成熟B淋巴细胞的选择和存活。

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期刊名称 British Journal of Clinical Pharmacology
作者
Xia Chen; Qian Zhao; Yong Hou; Ji Jiang; Wen Zhong; Wenxiang Wang; Xuejing Yao; Lin Li; Jianmin Fang; Fengchun Zhang; Pei Hu;
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作者单位

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年(卷),期 2016(82),1
年度 2016
页码 41–52
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
efficacy immunogenicity pharmacodynamics pharmacokinetics rheumatoid arthritis safety;

机译：功效;免疫原性;药效学;药代动力学;类风湿关节炎;安全性;

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专利

1. Pharmacokinetics, pharmacodynamics, short term efficacy and safety of RCT-18, a novel BLyS/APRIL fusion protein, in patients with rheumatoid arthritis [J] . Chen Xia, Zhao Qian, Hou Yong, British Journal of Clinical Pharmacology . 2016,第1期

机译：新型BLyS / APRIL融合蛋白RCT-18在类风湿关节炎患者中的药代动力学，药效学，短期疗效和安全性
2. Pharmacokinetics, pharmacodynamics, short term efficacy and safety of RCT‐18, a novel BLyS/APRIL fusion protein, in patients with rheumatoid arthritis [J] . Chen Xia, Zhao Qian, Hou Yong, British journal of clinical pharmacology . 2016,第1期

机译：新型BLyS / APRIL融合蛋白RCT-18在类风湿关节炎患者中的药代动力学，药效学，短期疗效和安全性
3. Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK‐1 Inhibitor, After Short‐Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials [J] . Vanhoutte Frédéric, Mazur Minodora, Voloshyn Oleksandr, Arthritis & rheumatology. . 2017,第10期

机译：菲尔替尼（一种选择性JAK-1抑制剂）的疗效，安全，药代动力学和药效学，在类风湿性关节炎短期治疗后：两项随机性IIA试验的结果
4. Differential Proteomic Profiling of Serum Samples from Rheumatoid Arthritis Patients by Two-step Abundant Protein Depletion [C] . Shanhua Lin, Hua Lin, Ted Jones, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：用两步丰富的蛋白耗尽来自类风湿性关节炎患者血清样品的差异蛋白质组学分析
5. Pharmacokinetic / pharmacodynamic / disease progression model of drug effects in a rat model of rheumatoid arthritis. [D] . Lon, Hoi Kei. 2013

机译：类风湿关节炎大鼠模型中药物作用的药代动力学/药效动力学/疾病进展模型。
6. Efficacy Safety Pharmacokinetics and Pharmacodynamics of Filgotinib a Selective JAK‐1 Inhibitor After Short‐Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials [O] . Frédéric Vanhoutte, Minodora Mazur, Oleksandr Voloshyn, -1

机译：类风湿关节炎的短期治疗后选择性JAK-1抑制剂非尔替尼的功效安全性药代动力学和药效学：两项IIa期随机试验的结果
7. SAT0139 A MULTICENTRE, RANDOMISED, DOUBLE-BLIND, PARALLEL ACTIVE-CONTROLLED CLINICAL TRIAL COMPARING PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY AND EXPLORATORY EFFICACY BETWEEN HLX01 AND EUROPE-SOURCED RITUXIMAB AS A NEW INDICATION IN CHINESE MODERATE TO SEVERE PATIENTS WITH RHEUMATOID ARTHRITIS [O] . Xiaofeng Zeng, Yongfu Wang, Zhenyu Jiang, 2019

机译：SAT0139多期，随机，双盲，并行主动控制的临床试验比较HLX01和欧洲 - 食宿的药代动力学，药效学，安全性和探索性疗效，作为中华色血肿性关节炎的中学患者的新迹象

Pharmacokinetics pharmacodynamics short term efficacy and safety of RCT‐18 a novel BLyS/APRIL fusion protein in patients with rheumatoid arthritis

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