The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects

机译：甲氧苄啶对人肝微粒体和健康受试者CYP2C8介导的罗格列酮代谢的影响

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摘要

AimsRosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the cytochrome P450 (CYP) enzyme CYP2C8. The anti-infective drug trimethoprim has been shown in vitro to be a selective inhibitor of CYP2C8. The purpose of this study was to evaluate the effect of trimethoprim on the CYP2C8 mediated metabolism of rosiglitazone in vivo and in vitro.

机译：罗格列酮是一种用于治疗2型糖尿病的噻唑烷二酮类抗糖尿病药物，主要由细胞色素P450（CYP）酶CYP2C8代谢。抗感染药甲氧苄啶在体外已显示为CYP2C8的选择性抑制剂。本研究的目的是评估甲氧苄啶对CYP2C8介导的罗格列酮体内和体外代谢的影响。

著录项

期刊名称 British Journal of Clinical Pharmacology
作者
M W Hruska; J A Amico; T Y Langaee; R E Ferrell; S M Fitzgerald; R F Frye;
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作者单位

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年(卷),期 2005(59),1
年度 2005
页码 70–79
总页数 10
原文格式 PDF
正文语种
中图分类药学;
关键词
rosiglitazone trimethoprim CYP2C8 drug interaction;

机译：罗格列酮;甲氧苄啶;CYP2C8;药物相互作用;

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专利

1. The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects. [J] . Hruska MW, Amico JA, Langaee TY, British Journal of Clinical Pharmacology . 2005,第1期

机译：甲氧苄啶对人肝微粒体和健康受试者体内CYP2C8介导的罗格列酮代谢的影响。
2. Effect of Curcuma longa on CYP2D6-and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects [J] . Al-Jenoobi Fahad Ibrahim, Al-Thukair Areej A., Alam Mohd Aftab, European journal of drug metabolism and pharmacokinetics . 2015,第1期

机译：姜黄素对人肝微粒体和健康人体内CYP2D6和CYP3A4介导右美沙芬代谢的影响
3. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. [J] . Ushijima K, Tsuruoka S, Tsuda H British Journal of Clinical Pharmacology . 2009,第2期

机译：酸果蔓汁抑制了人肝微粒体的双氯芬酸代谢，但对健康人没有抑制作用。
4. METABOLISM OF 2,2',3,4',5',6-HEXACHLOROBIPHENYL (CB149) BY LIVER MICROSOMES FROM RATS, HAMSTERS, GUINEA PIGS AND HUMANS [C] . Ohta C, Haraguchi K, Kato Y, International symposium on halogenated persistent organic pollutants . 2009

机译：大鼠，仓鼠，几内亚猪和人类肝脏微粒体对2,2'，3,4'，5'，6-六氯联苯（CB149）的代谢
5. System-dependent metabolism of drugs by cytochrome P450: The mechanistic basis for why human liver microsomes are superior to human hepatocytes at metabolizing midazolam but inferior at metabolizing desloratadine [D] . Kazmi, Faraz 2015

机译：细胞色素P450对系统的药物依赖性代谢：为什么人肝微粒体在代谢咪达唑仑时要优于人肝细胞，而在地氯雷他定的代谢时却不如人肝细胞的机理基础
6. The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects [O] . Rasmus S Pedersen, Per Damkier, Kim Brosen 2006

机译：人类CYP2C8基因型和氟伏沙明对罗格列酮在健康受试者体内药代动力学的影响
7. The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects [O] . Hruska, M W, Amico, J A, Langaee, T Y, 2005

机译：甲氧苄啶对人肝微粒体和健康受试者CYP2C8介导的罗格列酮代谢的影响
8. Effect of Gender on the Rate of Metabolism of Midazolam in Humans Using Liver Microsomes. [R] . Hinkle, K. L. 1997

机译：性别对人类利用肝微粒体对咪达唑仑代谢率的影响。

The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects

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