Human thiopurine methyltransferase activity varies with red blood cell age

机译：人硫嘌呤甲基转移酶活性随红细胞年龄而变化

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AimsInherited differences in thiopurine methyltransferase (TPMT) activity are an important factor in the wide interindividual variations observed in the clinical response to thiopurine chemotherapy. The aim of this study was to establish a population range for red blood cell (RBC) TPMT activity in children with acute lymphoblastic leukaemia (ALL) at disease diagnosis. An additional aim was to investigate factors that can influence TPMT activity within the RBC.

机译：目的硫嘌呤甲基转移酶（TPMT）活性的遗传差异是在对硫嘌呤化疗的临床反应中观察到的广泛个体差异的重要因素。这项研究的目的是确定急性淋巴细胞白血病（ALL）患儿在疾病诊断中红细胞（RBC）TPMT活性的人群范围。另一个目的是研究可影响RBC内TPMT活性的因素。

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期刊名称 British Journal of Clinical Pharmacology
作者
L Lennard; T S Chew; J S Lilleyman;
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作者单位

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年(卷),期 2001(52),5
年度 2001
页码 539–546
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
acute lymphoblastic leukaemia mercaptopurine red blood cells thioguanine nucleotides thioguanine thiopurine methyltransferase;

机译：急性淋巴细胞白血病;巯基嘌呤;红细胞;硫鸟嘌呤核苷酸;硫鸟嘌呤;硫嘌呤甲基转移酶;

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1. 中国人与白种人硫嘌呤甲基转移酶活性与分布的种族差异 [J] . 黄民, 姜文奇, 刘宇隆, 癌症（英文版） . 2000,第010期
2. Human thiopurine methyltransferase activity varies with red blood cell age. [J] . Lennard L, Chew TS, Lilleyman JS British Journal of Clinical Pharmacology . 2001,第5期

机译：人硫嘌呤甲基转移酶活性随红细胞年龄而变化。
3. Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells [J] . Karim H., Appell M.L., Fotoohi A. Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2013,第Null期

机译：三种测量红细胞和人类白血病细胞中硫嘌呤甲基转移酶活性的方法的比较
4. Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age. [J] . de-Boer NK, van-Bodegraven AA, de-Graaf P, Therapeutic Drug Monitoring . 2008,第3期

机译：硫唑嘌呤治疗期间全血细胞减少后，硫嘌呤S-甲基转移酶活性反常升高：对红细胞年龄的潜在影响。
5. Effects of Low Power Violet Laser Irradiation on Red Blood Cells Volume and Erythrocyte Sedimentation Rate in Human Blood [C] . Mustafa S. Al Musawi, M. S Jafaar, Naser M Ahmed, International Conference on Applied Physics and Engineering . 2017

机译：低功率紫光激光辐照对人血红细胞体积和红细胞沉降率的影响
6. Effect of varying levels of vitamin B-6 intake on lymphocyte mitogenic response and vitamin B-6 concentration in human peripheral blood mononuclear cells. [D] . Kwak, Ho-Kyung. 2001

机译：摄入不同水平的维生素B-6对人外周血单个核细胞中淋巴细胞促有丝分裂反应和维生素B-6浓度的影响。
7. Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity. [O] . D M Otterness, C L Szumlanski, T C Wood, 1998

机译：人硫嘌呤甲基转移酶的药物遗传学。带有末端外显子剪接连接突变导致活性降低。
8. Human thiopurine methyltransferase activity varies with red blood cell age [O] . Lennard, L, Chew, T S, Lilleyman, J S 2001

机译：人硫嘌呤甲基转移酶活性随红细胞年龄而变化
9. Effect of Red Blood Cell Storage on Cardiac Performance. Improved Myocardial Oxygen Delivery and Function during Constant Flow Coronary Perfusion with Low Oxy-Hemoglobin Affinity Human Red Blood Cells in Normothermic and Hypotherm [R] . Apstein, C. S., Dennis, R. C., Briggs, L., 1983

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Human thiopurine methyltransferase activity varies with red blood cell age

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