Establishment and characterization of a novel childhood acute lymphoblastic leukemia cell line HXEX-ALL1 with chromosome 9p and 17p deletions

摘要

BackgroundAlthough contemporary chemotherapy has improved the cure rate of childhood acute lymphoblastic leukemia (ALL) to nearly 90%, relapsed/refractory ALL is still a leading cause of tumor-related death in children. To clarify the underlying mechanisms of relapsed/refractory childhood ALL, researchers urgently need to establish novel cell models from patients with relapsed ALL after treatment with contemporary chemotherapy.