Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

摘要

BackgroundNotch signalling is essential for the development and maintenance of the colonic epithelium. Its inhibition induces a differentiation phenotype in vivo and reduces adenomas in APC^min mice. Whether Notch signals are also required in colorectal cancer (CRC) has remained elusive. Therefore, 64 CRC cell lines were analysed for the occurrence of proteolytically processed, active Notch.