Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets Phenotype and Function Between the Proximal and Distal Colon

摘要

Background & AimsMost knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103⁺ DC specialize in generating immune tolerance with the functionality of CD11b^+/− subsets being unclear. Information about human GI-DC is scarce, especially regarding regional specifications. Here, we characterized human DC properties throughout the human colon.