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High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production.

机译:酒精性肝硬化的白细胞介素6血清水平高白细胞产生增加。与IgA血清水平和淋巴因子产生相关。

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摘要

Hypergammaglobulinaemia and enhanced serum IgA levels are common in alcoholic liver cirrhosis. Interleukin-6 (IL-6), which is identical to B cell differentiation factor BSF2 and is implicated in various autoimmune diseases, has been studied in patients with alcoholic liver cirrhosis. Increased serum levels and spontaneous or induced production of IL-6 by peripheral blood monoclonal cells have been found. IL-6 production correlates closely with IgA serum levels and negatively with impaired interleukin-2 and interferon gamma production. This abnormality could be related to overproduction of immunoglobulins and immune disturbances observed in this disease.
机译:高丙种球蛋白血症和血清IgA水平升高在酒精性肝硬化中很常见。已对酒精性肝硬化患者进行了与白细胞分化因子BSF2相同且与多种自身免疫性疾病有关的白细胞介素6(IL-6)的研究。已经发现外周血单克隆细胞的血清水平升高和IL-6的自发或诱导产生。 IL-6的产生与IgA血清水平密切相关,与白介素2和干扰素γ产生负相关。这种异常可能与免疫球蛋白的过量产生和在该疾病中观察到的免疫紊乱有关。

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