Effect of erythropoietin on the incidence of acute kidney injury following complex valvular heart surgery: a double blind randomized clinical trial of efficacy and safety

摘要

IntroductionRecombinant human erythropoietin (EPO) is known to provide organ protection against ischemia-reperfusion injury through its pleiotropic properties. The aim of this single-site, randomized, case-controlled, and double-blind study was to investigate the effect of pre-emptive EPO administration on the incidence of postoperative acute kidney injury (AKI) in patients with risk factors for AKI undergoing complex valvular heart surgery.