A Partnership in the Making: Metabolic Phenotype Determined by the Combination of Dietary Fiber and the Gut Microbiome (FS07-03-19)

摘要

ObjectivesDietary fiber consumption improves cardiometabolic health, partly by enhancing microbial diversity and increasing production of butyrate in the distal gut. However, it is unclear whether the benefits associated with different types of fiber vary based on the gut microbiota composition. We surveyed nine different human gut microbial communities by characterizing them in germ-free mice and selected two communities based on their butyrate-producing capacity (“B”) and diversity (“D”) (i.e., high- vs. low-BD communities). Our objective was to assess the role of high- vs. low-BD communities on the metabolic effects elicited by the consumption of various dietary fibers.