AIM: To compare the nutritional status between alcoholic compensated cirrhotic patients and hepatitis C virus (HCV)-related cirrhotic patients with portal hypertension.METHODS: A total of 21 patients with compensated cirrhosis (14 with HCV-related cirrhosis and seven with alcoholic cirrhosis) who had risky esophageal varices were investigated. In addition to physical variables, including the body mass index, triceps skinfold thickness, and arm-muscle circumference, the nutritional status was also assessed using the levels of pre-albumin (pre-ALB), retinol-binding protein (RBP) and non-protein respiratory quotient (NPRQ) measured with an indirect calorimeter.RESULTS: A general assessment for the nutritional status with physical examinations did not show a significant difference between HCV-related cirrhosis and alcoholic cirrhosis. However, the levels of pre-ALB and RBP in alcoholic compensated cirrhotic patients were significantly higher than those in HCV-related compensated cirrhotic patients. In addition, the frequency of having a normal nutritional status (NPRQ ≥ 0.85 and ALB value > 3.5 g/dL) in alcoholic compensated cirrhotic patients was significantly higher than that in HCV-related compensated cirrhotic patients.CONCLUSION: According to our small scale study, alcoholic compensated cirrhotic patients can develop severe portal hypertension even with a relatively well-maintained liver function and nutritional status compared with HCV-related cirrhosis.
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机译:目的:比较酒精性代偿性肝硬化患者和丙型肝炎病毒相关性肝硬化门静脉高压症患者的营养状况。方法:共有21例代偿性肝硬化患者(其中HCV相关性肝硬化14例,酒精性肝硬化7例)。对有食管静脉曲张危险的人进行了调查。除了身体变量,包括体重指数,三头肌皮褶厚度和臂肌围,还使用白蛋白前(ALB),视黄醇结合蛋白(RBP)和非白蛋白前体的水平评估了营养状况。结果:通过体检对营养状况进行的一般评估并未显示HCV相关性肝硬化和酒精性肝硬化之间的显着差异。但是,酒精补偿的肝硬化患者的ALB和RBP水平明显高于HCV相关的肝硬化患者。此外,酒精性肝硬化患者的正常营养状态(NPRQ≥0.85和ALB值> 3.5 g / dL)的频率明显高于HCV相关性肝硬化患者的频率。结论:根据我们的小规模研究,与HCV相关的肝硬化相比,酒精补偿的肝硬化患者即使具有相对良好的肝功能和营养状况,也可以发展为严重的门静脉高压症。
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