D-二聚体在酒精性肝硬化患者中食管静脉曲张的早期预测

摘要

目的：探讨酒精性肝硬化患者食管静脉曲张的非创伤性预测指标的临床意义。方法选取2013-06～2015-01河源市人民医院消化内科收治的102例酒精性肝硬化患者，根据食管静脉曲张程度分组，另选同期体检的健康者22名作为对照组。比较各组间凝血四项、D-二聚体、血清胆碱酯酶（ CHE）、γ-谷氨酰转肽酶（γ-GGT）、血清白蛋白（ ALB）、门静脉内径（ PV）等水平变化。结果随着食管静脉曲张程度的加大， D-二聚体水平显著升高，PT、TT、APTT明显延长，FIB明显减少，CHE含量明显下降，γ-GGT明显升高，ALB明显下降，PV明显增大。结论尽早进行D-二聚体的检测，对于评估酒精性肝硬化患者食管静脉曲张程度具有重要的临床价值。%Objective To investigate the clinical value of trauma predictor to aim at esophageal varices in al-coholic cirrhosis patients.Methods One hundred and two alcoholic cirrhosis patients were collected in our hospital from June 2013 to January 2015.These patients were divided into several groups based on the degrees of esophageal varices and other 22 healthy people were chosen as the control group.The changes of four coagulation tests, D-dimer, serum cholinesterase(CHE), gamma glutamyl transpeptidase(γ-GGT), serum albumin(ALB) and the internal di-ameter of portal vein( PV) were compaired among the different groups.Results AS the degrees of esophageal varices increased in alcoholic cirrhosis patients, the levels of D-dimer,γ-GGT, PT, TT, APTT and PV increased significant-ly, and the levels of FIB, CHE and ALB decreased significantly.Conclusion Early detection of D-dimer has an im-portant clinical value for predicting the degrees of esophageal varices in alcoholic cirrhosis patients.