Extracellular Vesicles from Red Blood Cell Products Induce a Strong Pro-Inflammatory Host Response Dependent on Both Numbers and Storage Duration

摘要

BackgroundTransfusion of red blood cells (RBCs) is associated with adverse outcome, but the causative factor is unknown. Extracellular vesicles (EVs) have pro-inflammatory properties. We hypothesized that EVs released from both fresh and stored RBC products can induce a host inflammatory response in a dose-dependent manner.