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Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

机译：抗融合抑制剂的HIV-1变体的抗体介导的中和作用增强

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BackgroundHIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of monoclonal antibodies at neutralizing HIV-1 variants that are resistant to fusion inhibitors.

机译：背景HIV-1通常对任何一种抗逆转录病毒药物产生耐药性。联合使用抗逆转录病毒疗法以减少耐药性的发展对于控制HIV-1感染是必要的。在这里，为了评估抗体和融合抑制剂治疗组合的效用，我们研究了单克隆抗体在中和对融合抑制剂有抗性的HIV-1变体中的效力。

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期刊名称 Retrovirology
作者
Muntasir Alam; Takeo Kuwata; Kazuya Shimura; Masaru Yokoyama; Kristel Paola Ramirez Valdez; Kazuki Tanaka; Yasuhiro Maruta; Shinya Oishi; Nobutaka Fujii; Hironori Sato; Masao Matsuoka; Shuzo Matsushita;
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年(卷),期 2016(13),-1
年度 2016
页码 70
总页数 16
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
HIV Fusion inhibitor resistance Neutralization sensitivity;

机译：HIV;抗融合抑制剂;中和敏感性;

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专利

1. Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors [J] . Muntasir Alam, Takeo Kuwata, Kazuya Shimura, Retrovirology . 2016,第1期

机译：增强抗体介导的HIV-1变体中和抗融合剂的变体
2. GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [J] . Delino Nicole S., Aoki Manabu, Hayashi Hironori, Journal of neurosurgical sciences . 2018,第5期

机译：GRL-079是一种新型HIV-1蛋白酶抑制剂，对多药抗性HIV-1变体极其有效，并且具有抗抗性变体的出现的高遗传障碍
3. GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [J] . Delino Nicole S., Aoki Manabu, Hayashi Hironori, Antimicrobial agents and chemotherapy. . 2018,第5期

机译：GRL-079是一种新型HIV-1蛋白酶抑制剂，对多药抗性HIV-1变体极其有效，并且具有抗抗性变体的出现的高遗传障碍
4. Development of a Novel Fusion Inhibitor against T-20-resistant HIV-1 [C] . Shinya Oishi, Saori Ito, Hiroki Nishikawa American Peptide Symposium . 2009

机译：对T-20抗性HIV-1进行新型融合剂的开发
5. Structure based design of potent inhibitors against multidrug-resistant HIV-1 protease variants. [D] . Yedidi, Ravikiran S. 2009

机译：基于结构的抗多药HIV-1蛋白酶变体有效抑制剂的设计。
6. GRL-079 a Novel HIV-1 Protease Inhibitor Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [O] . Nicole S. Delino, Manabu Aoki, Hironori Hayashi, 2018

机译：GRL-079一种新型的HIV-1蛋白酶抑制剂对多药耐药的HIV-1变体具有极强的抵抗力并且对产生抗性变体具有高度的遗传屏障
7. Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors [O] . 2016

机译：抗融合抑制剂的HIV-1变体的抗体介导的中和作用增强

Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

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