Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis

摘要

BackgroundThe endoplasmic reticulum (ER) stress response participates in many chronic inflammatory and autoimmune diseases. In the current study, we sought to examine the contribution of ER stress transducers in the pathogenesis of three principal facets of allergic asthma: inflammation, airway fibrosis, and airways hyperresponsiveness.