PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3 amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

摘要

BackgroundViable embryos secrete preimplantation factor (PIF), a peptide that has autocrine effects where levels correlate with cultured embryos development. sPIF (PIF synthetic analog) promotes implantation by regulating decidual-cells immunity, adhesion, apoptosis and enhances trophoblastic cell invasion. Herein sPIF priming effects on non-decidualized endometrium and decidualized-stroma are investigated, assessing elements critical for effective embryo-maternal cross-talk, prior to and at implantation.