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Infectious Clones of Novel Lineage 1 and Lineage 2 West Nile Virus Strains WNV-TX02 and WNV-Madagascar

机译：新世系1和世系2西尼罗河病毒株WNV-TX02和WNV-马达加斯加的感染性克隆

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摘要

We report the generation of West Nile virus (WNV) infectious clones for the pathogenic lineage 1 Texas-HC2002 and nonpathogenic lineage 2 Madagascar-AnMg798 strains. The infectious clones exhibited biological properties similar to those of the parental virus isolates. We generated chimeric viruses and found that viral factors within the structural and nonstructural regions of WNV-TX contribute to the control of type I interferon defenses. These infectious clones provide new reagents to study flavivirus immune regulation and pathogenesis.

机译：我们报告了西尼罗河病毒（WNV）传染性克隆的致病谱系1 Texas-HC2002和非致病性谱系2马达加斯加-AnMg798菌株。传染性克隆表现出与亲本病毒分离株相似的生物学特性。我们产生了嵌合病毒，并发现WNV-TX的结构性和非结构性区域内的病毒因子有助于控制I型干扰素的防御。这些感染性克隆为研究黄病毒的免疫调节和发病机理提供了新的试剂。

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期刊名称 Journal of Virology
作者
Mehul S. Suthar; Margaret M. Brassil; Gabriele Blahnik; Michael Gale Jr.;
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年(卷),期 2012(86),14
年度 2012
页码 7704–7709
总页数 6
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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1. Serum neutralising antibody response of seronegative horses against lineage 1 and lineage 2 West Nile virus following vaccination with an inactivated lineage 1 West Nile virus vaccine [J] . Pearce Michael C., Venter Marietjie, Schouwstra Tjitske, The Journal of the South African Veterinary Association . 2013,第1期

机译：用灭活的谱系1西尼罗河病毒疫苗接种后，血清阴性马对谱系1和谱系2西尼罗河病毒的血清中和抗体反应
2. Serum neutralising antibody titres against a lineage 2 neuroinvasive West Nile Virus strain in response to vaccination with an inactivated lineage 1 vaccine in a European endemic area [J] . Feher Orsolya, Bakonyi Tamas, Barna Monika, Veterinary Immunology and Immunopathology . 2020,第1期

机译：血清中和抗体滴度，反对血管2个神经蛋白西尼罗病毒菌株，以响应欧洲地方区域的灭活谱系1疫苗接种疫苗
3. Evaluation of Cross-Protection of a Lineage 1 West Nile Virus Inactivated Vaccine against Natural Infections from a Virulent Lineage 2 Strain in Horses, under Field Conditions [J] . Serafeim C. Chaintoutis, Nikolaos Diakakis, Maria Papanastassopoulou, Clinical and vaccine immunology: CVI . 2015,第9期

机译：在野外条件下，针对马的有毒谱系2株对自然感染的谱系1西尼罗河病毒灭活疫苗的交叉保护评估
4. Equine Encephalomyelitis Outbreak Caused by a Genetic Lineage 2 West Nile Virus in Hungary [C] . Orsolya Kutasi, Imre Biksi, Tamas Bakonyi, Annual Convention of the American Association of Equine Practitioners . 2009

机译：匈牙利遗传素线2西尼罗病毒引起的马耳塞炎爆发
5. Functional analysis of flavivirus methyltransferase using an improved infectiouscDNA clone of West Nile virus. [D] . Zhou, Yangsheng. 2007

机译：使用改进的西尼罗河病毒感染性cDNA克隆对黄病毒甲基转移酶进行功能分析。
6. Evaluation of Cross-Protection of a Lineage 1 West Nile Virus Inactivated Vaccine against Natural Infections from a Virulent Lineage 2 Strain in Horses under Field Conditions [O] . Serafeim C. Chaintoutis, Nikolaos Diakakis, Maria Papanastassopoulou, 2015

机译：在野外条件下针对马的有毒谱系2株对自然感染的谱系1西尼罗河病毒灭活疫苗的交叉保护评估
7. Infectious Clones of Novel Lineage 1 and Lineage 2 West Nile Virus Strains WNV-TX02 and WNV-Madagascar [O] . M. S. Suthar, M. M. Brassil, G. Blahnik, 2012

机译：新型血统的传染性克隆1和谱系2西尼罗病毒菌株Wnv-TX02和Wnv-Madagascar
8. Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage [R] . Haddow, A. D., Schuh, A. J., Yasuda, C. Y., 2012

机译：寨卡病毒株的遗传特征：亚洲谱系的地理扩张

Infectious Clones of Novel Lineage 1 and Lineage 2 West Nile Virus Strains WNV-TX02 and WNV-Madagascar

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