Adult blowflies (Phormia regina Meigen) injected with the octopaminergic drug demethylchlordimeform (10 μg per fly) exhibited enhanced proboscis extension responses when their tarsae were touched to water or aqueous sucrose. They drank more water than saline-injected control flies did but the quantity imbibed was within the normal fluid intake capacity. They became grossly hyperphagic when offered 1 M sucrose, doubling (and in some cases even tripling) their initial body weights. Three other drugs enhanced tarsal responsiveness and induced hyperphagia: DL-octopamine, clonidine (which is known to stimulate octopaminergic receptors in insects), and pargyline, a monoamine oxidase inhibitor. Yohimbine, an antagonist of one class of octopaminergic receptor in insects, prevented the hyperphagia induced by all four drugs. Dopamine, 5-hydroxytryptamine, and DL-norepinephrine failed to cause hyperphagia. These results suggest that octopaminergic receptors in the nervous system of the blowfly positively modulate feeding and drinking behavior.
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机译：注射章鱼胺能药物去甲基氯肟酮（每只蝇10μg）的成年蝇（Pregmia regina Meigen），当其接触水或蔗糖水溶液时，其长鼻延长反应增强。他们喝的水比注射生理盐水的对照蝇多，但是吸收的水量在正常的液体摄入量之内。当提供1 M蔗糖时，它们变得严重高食，将其初始体重加倍（有时甚至是三倍）。其他三种药物可增强反应，并引起食欲亢进：DL-章鱼胺，可乐定（已知可刺激昆虫中的章鱼胺受体）和Pargyline（一种单胺氧化酶抑制剂）。育亨宾是昆虫中一种章鱼胺受体的拮抗剂，它可以防止所有四种药物引起的食欲亢进。多巴胺，5-羟基色胺和DL-去甲肾上腺素未能引起食欲亢进。这些结果表明，蝇类神经系统中的章鱼胺能受体正调节着饮食行为。
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