首页> 美国卫生研究院文献>Pakistan Journal of Medical Sciences >Association of single Nucleotide Missence Polymorphism Val109Asp of Omentin-1 gene and coronary artery disease in Pakistani population: Multicenter study
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Association of single Nucleotide Missence Polymorphism Val109Asp of Omentin-1 gene and coronary artery disease in Pakistani population: Multicenter study

机译:Omentin-1基因单核苷酸缺失多态性Val109Asp与巴基斯坦人群冠心病的关系:多中心研究

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摘要

Background & Objective:Coronary artery disease (CAD) is a most important cause of morbidity and mortality worldwide as well as in Pakistan. Recent studies have shown that the combination of obesity, insulin resistance and fluctuation in circulating adipocytokines levels is associated with the pathogenesis of coronary artery disease. Omentin-1 is recently found adipocytokine that is highly expressed in visceral adipose tissue. It has anti- inflammatory properties and is negatively correlated with ischemic heart disease. Therefore, this study was designed to investigate the relationship between omentin-1 Val109Asp polymorphism and CAD in Pakistani population.
机译:背景与目的:冠状动脉疾病(CAD)是全世界乃至整个巴基斯坦发病和死亡的最重要原因。最近的研究表明,肥胖,胰岛素抵抗和循环脂肪细胞因子水平的波动与冠心病的发病机理有关。最近发现Omentin-1是在内脏脂肪组织中高度表达的脂肪细胞因子。它具有抗炎特性,并且与缺血性心脏病呈负相关。因此,本研究旨在调查巴基斯坦人口中omentin-1 Val109Asp多态性与CAD的关系。

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