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Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis

机译：吉西他滨和卡铂通过抑制DNA合成和增加细胞凋亡而在宫颈癌细胞中表现出协同细胞毒性

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BackgroundThe present study aims to investigate the subunit expression and enzyme activity of ribonucleotide reductase in cervical cancer patients, and detect the combined effect of the ribonucleotide reductase inhibitor gemcitabine and the chemotherapeutic agent carboplatin on cervical cancer cell lines.

机译：背景本研究旨在研究子宫颈癌患者中核糖核苷酸还原酶的亚基表达和酶活性，并检测核糖核苷酸还原酶抑制剂吉西他滨和化学治疗剂卡铂对宫颈癌细胞系的联合作用。

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期刊名称 OncoTargets and therapy
作者
Guixiu Jin; Jing Zhao; Hongyan Qi; Meng Lou; Xia Liu; Yu Qu; Lingjun Zhao; Weifeng Zhang; Jimin Shao; Huizhen Zhong;
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作者单位

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年(卷),期 2013(6),-1
年度 2013
页码 1707–1717
总页数 11
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
cervical cancer ribonucleotide reductase gemcitabine carboplatin;

机译：宫颈癌;核糖核苷酸还原酶;吉西他滨;卡铂;

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专利

1. Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis [J] . Guixiu Jin, Jing Zhao, Hongyan Qi, OncoTargets and therapy . 2013,第6期

机译：吉西他滨和卡铂通过抑制DNA合成并增加细胞凋亡而在宫颈癌细胞中表现出协同细胞毒性
2. Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3 [J] . Cancer biology & therapy . 2012,第11期

机译：Aurora激酶抑制剂VE 465通过诱导凋亡和下调组蛋白3协同增强卵巢癌细胞中卡铂的细胞毒性
3. Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells [J] . Liudmila L. Kodach, Carina L. Bos, Nelson Durán, Carcinogenesis . 2006,第3期

机译：紫胶素协同增加5-氟尿嘧啶的细胞毒性，诱导细胞凋亡并抑制人结肠直肠癌细胞中Akt介导的信号转导
4. Synergistic Combination of Fluoro Chalcone and Doxorubicin on HeLa Cervical Cancer cells by Inducing Apoptosis [C] . Retno Arianingrum, Indyah Sulistyo Arty, Sri Atun International Conference on Chemistry, Chemical Process and Engineering . 2017

机译：通过诱导细胞凋亡协同氟醌和多柔比蛋白对HeLa宫颈癌细胞的协同组合
5. Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes [D] . Han, Jing Y. 2009

机译：3,3'-二吲哚基甲烷诱导的人C33A宫颈癌细胞死亡的机制：内质网应激，细胞凋亡以及生长停滞和DNA损伤基因的作用
6. Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3 [O] . Siqing Fu, Yanfang Li, Jie Huang, 2012

机译：Aurora激酶抑制剂VE 465通过诱导凋亡和下调组蛋白3协同增强卵巢癌卡铂的细胞毒性
7. Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis [O] . Huizhen Zhong, Guixiu Jin, Hongyan Qi, 2013

机译：吉西他滨和卡铂通过抑制DNA合成和增加细胞凋亡，展示宫颈癌细胞中的协同细胞毒性

Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis

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