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Biogenesis of mitochondria: the mitochondrial gene (aap1) coding for mitochondrial ATPase subunit 8 in Saccharomyces cerevisiae.

机译:线粒体的生物发生:酿酒酵母中编码线粒体ATPase亚基8的线粒体基因(aap1)。

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摘要

A mitochondrial gene (denoted aap1) in Saccharomyces cerevisiae has been characterized by nucleotide sequence analysis of a region of mtDNA between the oxi3 and oli2 genes. The reading frame of the aap1 gene specifies a hydrophobic polypeptide containing 48 amino acids. The functional nature of this reading frame was established by sequence analysis of a series of mit- mutants and revertants. Evidence is presented that the aap1 gene codes for a mitochondrially synthesized polypeptide associated with the mitochondrial ATPase complex. This polypeptide (denoted subunit 8) is a proteolipid whose size has been previously assumed to be 10 kilodaltons based on its mobility on SDS-polyacrylamide gels, but the sequence of the aap1 gene predicts a molecular weight of 5,815 for this protein.
机译:酿酒酵母中的线粒体基因(表示为aap1)已通过对oxi3和oli2基因之间mtDNA区域的核苷酸序列分析进行了表征。 aap1基因的阅读框指定了包含48个氨基酸的疏水多肽。该阅读框的功能性质是通过一系列mit突变体和回复体的序列分析确定的。证据表明,aap1基因编码与线粒体ATPase复合体相关的线粒体合成多肽。该多肽(表示为亚基8)是一种蛋白脂质,根据其在SDS-聚丙烯酰胺凝胶上的迁移性,其大小先前被假定为10道尔顿,但aap1基因的序列预测该蛋白的分子量为5,815。

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